The polycomb group transcriptional modifier Bmi1 is often upregulated in numerous cancers and is intensely involved in normal and cancer stem cells, and importantly is as a prognostic indicator for some cancers, but its role in breast cancer remains unclear.Here, we found Bmi1 overexpression in 5-Fu (5-fluorouracil)-resistant MCF-7 cells (MCF-7/5-F
The dirigible Italia crashed onto the Arctic sea ice north-east of the Svalbard archipelago on 25 May 1928 at 10:33 GMT while travelling back to her base from the North Pole.Only eight of the 16 crew members survived: one was killed upon impact, one did not survive the post-crash ordeal and six were trapped in the airship envelope (i.e., the balloo
The article describes the clinical case of a difficult systemic juvenile arthritis refractory to traditional immunosuppressant and TNF blocker therapy.The disease was characterized by such extra-articulate manifestations as fever, lymphadenopathy, hepatolienomegaly, polyorrhymenitis, generalized joint affection and high laboratory activity indicato
Background: Women with diminished ovarian reserve (DOR) have fewer oocytes than would be expected at their age.While a decrease in ovarian reserve is a normal part of ageing, some women experience a decrease beyond what is physiologically expected due to normal age-related decline.Optimal management of women with DOR remains unclear, with medically